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Nefopam Hydrochloride: Uses,Dosage,Side Effects

Generic Name
Nefopam Hydrochloride
Therapeutic Class:
Analgesic, Anti Inflammatory (Non opioid analgesics, Non-Opioid Analgesics)

Indications:
Nefopam Hydrochloride is indicated for the relief of acute pain, including post-operative, dental, musculoskeletal, and acute traumatic pain. It is also indicated in chronic pain like cancer pain.

Presentation:
Nefopam Tablet: Each film-coated tablet contains Nefopam Hydrochloride INN 30 mg.
Nefopam Injection: Each ampoule contains 1ml solution of Nefopam Hydrochloride INN 20 mg.

Description:
Nefopam Hydrochloride is a centrally acting analgesic with a rapid onset of action. The main site of action appears to be in the central nervous system both at the brain and spinal levels. In vitro experiments have shown Nefopam to inhibit the re-uptake of various catecholamines (including noradrenaline, serotonin, and dopamine). It is possible that the mechanism of action of nefopam is at least in part by altering the levels of these neuromodulators in the brain and at the spinal level.

Dosage & Administration:
Tablet:
  • Adults: Dosage may range from 30 to 90 mg three times daily depending on response. The recommended starting dosage is 2 tablets three times daily.
  • Elderly: Elderly patients may require reduced dosage due to slower metabolism. It is strongly recommended that the starting dose does not exceed 1 tablet 3 times daily.
Injection: 
  • Adult: 20 mg by IM injection, repeated every 6 hours if necessary. It also be given by slow IV injection in a similar dose.
  • Children: Not recommended for children under the age of 12 years.
Side Effects:
Nefopam Hydrochloride is generally well tolerated. However, the most common side effects are nausea, nervousness, dry mouth, lightheadedness, and urinary retention. The less common side-effects are vomiting, blurred vision, drowsiness, sweating, insomnia, headache, confusion, hallucinations, tachycardia, and aggravation of angina.

Precautions:
Nefopam Hydrochloride should be used with caution in patients with glaucoma and with or at risk of urinary retention. Caution should be exercised when Nefopam is administered concurrently with tricyclic antidepressants. Caution should also be exercised in patients with a history of ischaemic heart disease.

Use in Pregnancy & Lactation:

Pregnancy: Nefopam Hydrochloride is not recommended for pregnant women.
Lactation: Evidence suggests that nefopam is excreted in human milk. A decision should be made whether to discontinue nursing or discontinue the medication, taking into account the potential for adverse effects for the fetus and the importance of treatment to the mother.

Overdose:
Nefopam toxicity is manifested by neurological symptoms (convulsions, hallucinations, agitation) and cardiovascular response (tachycardia with hyperdynamic circulation). Supportive treatment is suggested including gastric lavage, forced emesis, and diuresis. Oral administration of activated charcoal may help prevent absorption. Convulsions and hallucinations may be controlled with diazepam. Beta-adrenergic blockers may be of use in controlling cardiovascular complications.

Storage:
Keep out of the reach of children. Store in a cool, dry place, away from heat and direct light.

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