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Trimetazidine Dihydrochloride: Uses,Dosage,Side Effects

Generic Name
Trimetazidine Dihydrochloride
Therapeutic Class:
Cardiovascular

Indications:
Trimetazidine is indicated for-
Ischaemic heart disease (angina pectoris, sequelae of infarction).

Presentation:
Trimetazidine Dihydrochloride 20 tablet: Each film-coated tablet contains Trimetazidine Dihydrochloride BP 20 mg.
Trimetazidine Dihydrochloride 35 MR tablet: Each modified-release tablet contains Trimetazidine Dihydrochloride BP 35 mg.

Description:
Trimetazidine is a unique antianginal and anti-ischaemic agent that display anti-ischemic effects without inducing hemodynamic changes and improves the status of the ischaemic myocardium. The drug exerts its antianginal effects through a direct cytoprotective action on the myocardium, thereby avoiding the side-effects of impaired left ventricular function, excessive peripheral vasodilation, and other disadvantages associated with the use of comparator antianginal agents

Dosage & Administration:
One 20 mg tablet thrice daily after meals. No dosage adjustments are required in patients with impaired renal and hepatic function.
One 35 mg MR tablet twice daily at mealtimes in the morning and evening.

Side Effects:
Trimetazidine is safe and well-tolerated. The most commonly encountered side effects are gastric discomfort, nausea, headache, and vertigo. However, the side effects are mild and non-specific.

Precautions:
N/A

Use in Pregnancy & Lactation:
Pregnancy: Studies in animals have not demonstrated a teratogenic effect. However, in the absence of clinical data and for safety reasons, the prescription should be avoided during pregnancy.
Nursing Mothers: There is no information on the secretion of Trimetazidine into breast milk. However, breastfeeding should be discontinued if the use of Trimetazidine is considered essential.

Interaction:
No drug interactions have so far been reported. In particular, no interactions of Trimetazidine with beta-blockers, calcium antagonists, nitrates, heparin, hypolipidemic agents, or digitalis have been reported.

Storage:
Keep in a dry place away from light and heat. Keep out of the reach of children.

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