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Paracetamol 665 mg: Uses,Dosage,Side Effects

Generic Name
Paracetamol 665 mg
Therapeutic Class:
 Analgesic, Anti Inflammatory (Non opioid analgesics)

Indications:
Paracetamol 665 mg is effective for the relief of persistent pain associated with osteoarthritis and muscle aches and pains such as backache. It also provides effective temporary relief from the pain and discomfort associated with headache, tension headache, period pain, toothache and pain after dental procedures, cold & flu. Paracetamol 665 mg tablet is also effective in reducing fever.

Presentation:
Paracetamol 665 mg: Each tablet contains Paracetamol BP 665mg.

Description:
Paracetamol 665 mg is the preparation of Paracetamol 665 mg extended-release formulation of bilayer tablet. Immediate release formulation for immediate response and extended-release formulation for the extended response of 8 hours.

Dosage & Administration:
Adults and children over 12 years: 2 tablets, swallowed whole, every 6 to 8 hours (maximum of 6 tablets in any 24 hours). The tablets must not be crushed.

Precautions:
Paracetamol 665 mg should be administered with caution to patients with hepatic or renal dysfunction.

Pregnancy & Lactation:
Paracetamol 665 mg tablet has been categorized as Category A.Lactation: Paracetamol is excreted in breast milk. It has been reported that from a single 665 mg dose, 0.04 to 0.23% will be available for ingestion by the infant. These results are based on immediate-release preparations of paracetamol. There is no data available on the excretion of extended-release paracetamol preparations in breast milk.

Interaction:
Anticoagulant dosage may require reduction if paracetamol medication is prolonged. Paracetamol absorption from immediate-release preparations is increased by drugs that increase gastric emptying e.g. metoclopramide and decreased by drugs that decrease gastric emptying, e.g. propantheline, antidepressants with anticholinergic properties, narcotic analgesics. However, concurrent administration of metoclopramide may reduce the absorption of paracetamol from this extended-release dosage form, as it accelerates gastric emptying and intestinal transit. Paracetamol may increase chloramphenicol concentrations. The likelihood of paracetamol toxicity may be increased by the concomitant use of enzyme-inducing agents such as alcohol or anticonvulsant drugs.

Overdose:
Paracetamol overdose may cause hepatic failure due to prolonged exposure of paracetamol in the blood from the extended-release form. Immediate medical management is required in the event of overdose even symptoms of overdose are not present.

Storage:
Do not store above 30 o C. Keep away from light and out of the reach of children.

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