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Tioconazole: Uses,Dosage,Side Effects

Generic Name
Tioconazole
Therapeutic Class:
 used in Vaginal and Vulval condition, Topical Antifungal preparations

Indications:
Tioconazole is indicated for the local treatment of vulvovaginal candidiasis (moniliasis).

Presentation:
Tioconazole Ointment: Each gram ointment contains Tioconazole BP 65 mg.

Description:
Tioconazole is a topical antifungal agent. It is a broad-spectrum antifungal agent that inhibits the growth of human pathogenic yeasts. It exhibits fungicidal activity in-vitro against Candida albicans, other species of the genus Candida, and against Torulopsis glabrata.

Dosage & Administration:
Tioconazole has been found to be effective as a single dose treatment for vulvovaginal candidiasis. Insert one applicator-full (about 4.6 g) intravaginally. Administration of Tioconazole just prior to bedtime may be preferred.

Side Effects:
Burning and itching were the most frequent side effects occurring in approximately 6% and 5% of the patients respectively. There were occasional reports (less than 1%) of other side effects including irritation, discharge, vulvar edema and swelling, vaginal pain, dysuria, nocturia, dyspareunia, dryness of vaginal secretions, desquamation.

Precautions:
Tioconazole is intended for intravaginal administration only. Administration of Tioconazole just prior to bedtime may be preferred. The Tioconazole ointment base may interact with rubber or latex products such as condoms; therefore, use of such products within 72 hours following treatment is not recommended.

Use in Pregnancy & Lactation:
Pregnancy: Pregnancy category C. Tioconazole should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Lactation: It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, nursing should be temporarily discontinued while Tioconazole is administered.

Storage:
Do not store above 30 O C. Keep away from light and out of the reach of children.

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