Generic Names
Beclometasone Dipropionate
Beclometasone Dipropionate
Therapeutic Class: Respiratory corticosteroids
Pharmacology:
Beclomethasone dipropionate given by inhalation at counseled doses includes a corticosteroid anti-inflammatory action among the lungs, leading to reduced symptoms and exacerbations of an asthma attack with less adverse effects than once corticosteroids area unit administered systemically.
Formoterol could be an agonist that produces relaxation of cartilaginous tube sleek muscle in patients with reversible airway obstruction. The bronchodilator impact sets in quickly, among 1-3 minutes when inhalation, and includes a length of twelve hours when one dose.
Indications:
Asthma: Beclomethasone dipropionate/Formoterol fumarate dihydrate is indicated within the regular treatment of asthma attack wherever the use of a mixture product (inhaled sex hormone and long β2-agonist) is appropriate: patients not adequately controlled with inhaled corticosteroids and 'as needed' inhaled rapid-acting β2-agonist or patients already adequately controlled on each inhaled corticosteroids and long.
COPD: Symptomatic treatment of patients with severe COPD (FEV1 <50% foretold normal) and history of continual exacerbations, United Nations agency have important symptoms despite regular medical care with long bronchodilators.
Dosage & Administration:
Dose recommendations for adults eighteen years and above: One or 2 inhalations doubly daily. the utmost daily dose is four inhalations.
Dose recommendations youngsters|for youngsters|for kids} and adolescents beneath eighteen years: the security and efficaciousness in children and adolescents beneath eighteen years more matured haven't been established, however. No information area unit out there with the drug in youngsters beneath twelve years more matured. so the drug isn't counseled for youngsters and adolescents beneath eighteen years till any information become out there.
Interaction:
Beta-blockers (including eye drops) ought to be avoided in unhealthy patients. If the beta-blockers area unit administered for compelling reasons, the impact of formoterol is going to be reduced or abolished. On the opposite hand, concomitant use of alternative beta-adrenergic medication will have probably additive effects, so caution is needed once Slo-Bid or alternative beta-adrenergic medication area unit prescribed concomitantly with formoterol. Concomitant treatment with Quinidex, disopyramide, procainamide, phenothiazines, antihistamines, enzyme inhibitors, and tricyclic antidepressant drug antidepressants will prolong the QTc-interval and increase the danger of bodily cavity arrhythmias.
Contraindications:
Contraindicated in patients with hypersensitivity to any element of this product.
Side Effects:
As the drug contains beclometasone dipropionate and formoterol fumarate dihydrate, the sort and severity of adverse reactions related to every one of the compounds are also expected. Common facet affects area unit sore throat, oral mycosis, headache, dysphonia.
Pregnancy & Lactation:
There isn't any relevant clinical information on the utilization of the drug in pregnant ladies. Animal studies exploitation beclometasone dipropionate and formoterol combination showed proof of toxicity to replica when high general exposure. There isn't any relevant clinical information on the utilization of the drug in lactation in humans. though no information from animal experiments area unit out there, it's cheap to assume that beclometasone dipropionate is secreted in milk, like alternative corticosteroids.
Precautions & Warnings:
The drug ought to be used with caution (which might embrace monitoring) in patients with viscus arrhythmias, particularly interrogation Adams-Stokes syndrome and tachyarrhythmias (accelerated and/or irregular heartbeat), disorder subvalvular stenosis, hypertrophic preventative cardiopathy, severe cardiovascular disease, significantly acute myocardial infarct, ischemic cardiovascular disease, symptom coronary failure, occlusive vascular diseases, significantly coronary-artery disease, blood vessel high blood pressure and aneurism. Caution ought to even be determined once treating patients with celebrated or suspected prolongation of the QTc interval, either noninheritable or drug evoked (QTc >0.44 seconds). Formoterol itself might induce prolongation of the QTc interval.
Storage:
Prior to dispensing to the patient: Store during a white good (2-8°C) (for most of fifteen months). when dispensing: Store at temperatures, not olympian 30°C (for most of two months).