ROXATIDINE ACETATE HCI
Roxatidine acetate hydrochloride is an H-receptor antagonist that acts without interacting.
Indications: duodenal and benign gastric ulcers and reflux oesophagitis; prophylaxis or recurrent gastric or duodenal ulcers and as maintenance therapy
Precautions: Patients hypersensitive to roxatidine acetate, with malignant gastric ulcers, or anuria. In pregnant and lactating women, roxatidine should only be used if strictly indicated. Not recommended in patients younger than 14 years.
S/E: Occasional headache, g.i disturbances, rarely dizziness, sleep disturbances, restlessness and drowsiness, visual disturbances, pain in muscles and joints, hypersensitivity reactions. Very rarely, a change in pulse rate. Transient impairment of sexual drive.
Dosage: Adults- the usual dose is 150mg once daily in the evening or 75mg twice daily for 4-6 weeks. Maintenance therapy, 75mg daily in the evening Do not chew the tablet but swallow whole. Dosage is required to be adjusted as per the creatinine clearance in patients with impaired renal function.