LANSOPRAZOLE: Capsule
Ind: Lansoprazole is indicated in the treatment of conditions where a reduction of gastric acid secretion is required, such as- duodenal ulcer, gastric ulcer, peptic ulcer associated with Helicobacter pylori, NSAID associated peptic ulcer, gastro-oesophageal reflux disease, acid-related dyspepsia & Zollinger-Ellison syndrome.
C/l: Hypersensitivity to the ingredients of this drug.
S/E: These include- headache, diarrhea, rashes, pruritus, dizziness, urticaria, nausea and vomiting, constipation, flatulence & abdominal pain.
Precaution &warnings: Lansoprazole should be administered with care in the following patients-
- patients with a history of drug hypersensitivity,
- patients with hepatic dysfunction,
- in pregnant women or women having possibilities of being pregnant only if the expected therapeutic benefit is thought to outweigh any possible risk,
- it is advisable to avoid in nursing mothers,
- the safety of lansoprazole in children has not been established.
Dosage & Admin: Benign gastric ulcer- 30mg daily in the morning for 8 weeks. Duodenal ulcer- 30mg daily in the morning for 4 weeks; maintenance 15mg daily. NSAID associated duodenal or gastric ulcer- 15mg to 30mg once daily for 4 weeks, followed by a further 4 weeks if not healed completely. Zollinger-Ellison syndrome (and other hypersecretory conditions)- initially 60mg once daily adjusted according to response; daily doses of 120mg or more are given in two divided doses. Gastro-oesophageal reflux disease- 30mg daily in the morning for 4 weeks, followed by a further 4 weeks if not fully healed; maintenance therapy may be required, 15-30mg daily. Acid- related dyspepsia- 15mg to 30mg daily in the morning for 2-4 weeks.
Interactions: In clinical studies, lansoprazole does not show any significant interactions with warfarin, indomethacin, aspirin, ibuprofen, phenytoin, prednisolone, antacids, or diazepam in healthy subjects; but when administered concomitantly with theophylline, a minor increase (10%) in the clearance of theophylline was seen, which is unlikely to be of clinical importance.